Study of Efficacy of Aqueous and Methanolic Extract of Green Tea on the Process of Opened Skin Wounds Healing in Male (NMRI) Mice Race

Green tea used for year has a popular cancer preventive activity. Researchers have showed green tea inhibited growth of cancer in the animals. This research has been done with awareness of positives effect of green tea, which is approved by researchers and the importance of treatment of opened skin wound. This work has been done experimentally. There were 56 male mice in 7 different groups. Different dose of water and alcohol such as 50, 150 and 300 m L were injected. After anaesthetizing the mice, skin wound was created on the back of the mice by a 6-mm punch. While the mice in control group were treated by normal saline, water and alcohol extract of green tea was injected around the wound on the back of each mouse. The dimensions of ulcers and the recovery percent of the wound in the 1 st , 3 rd , 5 th , 7 th , 10 th , 13 th and 15 th day of study were measured. Furthermore, the needful time for recovery was evaluated. Some histological studies were done as well. Two Specimen of wounds were supplied at 4 th , 7 th and 15 th day of the study. In this way, fibroblasts, inflammation, epitheleum and endothelial cell of blood vessels from the wounds were studied. The results show that there are no significant differences among control, water and alcohol groups in recovery processes ( p > 0.05 (. Evaluation of recovery processes showed there were significant differences among these groups on 7 th day of study ( p < 0.01 ( . Evaluation of recovery processes showed there were significant differences among three injected doses of study ( p < 0.001). The degree of differences in fibroblasts, inflammation and epithelium distortion in different days for 6 groups ( p < 0.05) was meaningful. According to these findings, although both water and alcohol extracts of green tea speed up the wound healing, there isn&#039;t any difference between the uses of water or alcohol extracts.